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Role of Macrophage Inhibitory Cytokine-1 in Tumorigenesis and Diagnosis of Cancer

 

Abstract
Macrophage inhibitory cytokine-1 (MIC-1), a transforming growth factor-B superfamily cytokine, is involved in tumor pathogenesis, and its measurement can be used as a clinical tool for the diagnosis and management of a wide range of cancers. Although generally considered to be part of the cell’s antitumorigenic repertoire, MIC-1 secretion, processing, and latent storage suggest a complex, dynamic variability in MIC-1 bioavailability in the tumor microenvironment, potentially modulating tumor progression and invasiveness. (Cancer Res 2006; 66(10): 4983-6)

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Tuesday, 20 August 2019 07:14