×

Message

EU e-Privacy Directive

This website uses cookies to manage authentication, navigation, and other functions. By using our website, you agree that we can place these types of cookies on your device.

View e-Privacy Directive Documents

You have declined cookies. This decision can be reversed.

Aging and Immune Function: Molecular Mechanisms to Interventions

 

Abstract

 

The immune system of an organism is an essential component of the defense mechanism aimed at combating pathogenic stress. Age-associated immune dysfunction, also dubbed “immune senescence,” manifests as increased susceptibility to infections, increased onset and progression of autoimmune diseases, and onset of neoplasia. Over the years, extensive research has generated consensus in terms of the phenotypic and functional defects within the immune system in various organisms, including humans. Indeed, age-associated alterations such as thymic involution, T cell repertoire skewing, decreased ability to activate naïve T cells and to generate robust memory responses, have been shown to have a causative role in immune decline. Further, understanding the molecular mechanisms underlying the generation of proteotoxic stress, DNA damage response, modulation of ubiquitin proteasome pathway, and regulation of transcription factor NFκB activation, in immune decline, have paved the way to delineating signaling pathways that cross-talk and impact immune senescence. Given the role of the immune system in combating infections, its effectiveness with age may well be a marker of health and a predictor of longevity. It is therefore believed that a better understanding of the mechanisms underlying immune senescence will lead to an effective interventional strategy aimed at improving the health span of individuals. Antioxid. Redox Signal. 14, 1551–1585.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061194/

Attachments:
Download this file (Aging and Immune Function- Molecular Mechanisms to Interventions.pdf)Aging and Immune Function- Molecular Mechanisms to Interventions.pdf[Aging and Immune Function- Molecular Mechanisms to Interventions]552 kB
REGISTERED: Handelsregister Schwyz
COMPANY NUMBER: CH-1029-379-06
TAX NUMBER: 1029-379-06
Copyright © 2017. All Rights Reserved.
Institute for Biomodulation Medicine AG

SCHWERZISTRASSE 4, CH-8807 FREIENBACH (SZ)
PHONE: +41 41 5003753 FAX: +41 41 5003754
EMAIL: INFO@BIOMODULATION.ORG

logo

INSTITUTE FOR BIOMODULATION
MEDICINE

0.png0.png4.png5.png9.png7.png1.png1.png
Today3
Yesterday472
This week475
This month8337
Total459711

Tuesday, 19 February 2019 00:10