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Typical Biomodulator - Colostrum Immuno – Protein Supplement

BENEFITS -  SIDE EFFECTS -  AND COMPOSITION

WHAT IS COLOSTRUM? Colostrum is the first collection of a thick creamy liquid, without blood or  infection, produced by the mammary gland of a parturient mother shortly after birth, usually within the  first 6 hours.  Colostrum is very important part of breast milk and lays down the immune system and  confers growth factors and other protective factors for the young ones in mammals. This is the  source of passive immunity achieved by the mother and is transferred to the baby. This is the major  source of secretory IgA and gives protection against gastrointestinal infections.

WHAT ARE THE POSSIBLE BENEFITS OF COLOSTRUM?

Colostrum is known to have benefits such as  passive immunization, benefits immunodeficient  patients. The feasibility of obtaining surface immunoglobulin suitable for oral use, which may in future be administered to immunodeficient patients with gastrointestinal manifestations, from human  colostrum and milk.
Human and bovine colostrum have many similarities barring that bovine colostrum can be obtained in  large quantity, so bovine colostrum may be as beneficial as human colostrums on various disorders in human beings.

Lactoferrin (LF) exhibits antibacterial, antifungal, antiviral, antiparasitice, and antitumoral activities.
It is protective with regard to intestinal epithelium, promotes bone growth, and accelerates the recovery of immune system function in immunocompromised animals. Lactoferrin (LF) was tried in the
treatment of hepatitis C infection and the intestinal form of graft-versus-host disease (GvHD).
A proline-rich polypeptide (PRP) demonstrated a variety of immunotropic functions, including the promotion of T-cell maturation and inhibition of autoimmune disorders. PRP, in the form of chewable  tablets (CLP) was  found to improve or stabilize the health status of Alzheimer's  disease patients.
Casein and casein-derived peptides showed protective activities in enamel demineralization and  as caries-preventing agents. The protein hydrolyzates were also protective diminished colicky symptoms in infants.

Glycomacropeptide (GMP), a peptide derived from kappa-casein, exhibited various antibacterial  and antithrombotic activities.

Alpha-lactalbumin (LA) demonstrated antiviral, antitumoral and anti-stress properties. LA-enriched diets were anxiolytic, lowered blood pressure in rats, prevented diarrhea, and led to a better weight   gain in malnourished children.

HAMLET, a complex of LA and oleic acid, was effective in patients with cutaneous papillomas.
Lysozyme found application in infant formulas, the treatment of periodentitis, and the prevention of tooth decay. Milk enriched in lysozyme was used in feeding premature infants suffering from concomitant diseases. Interesting, antibacterial properties were exhibited by lactoperoxidase. Both lysozyme and lactoperoxidase required cooperative action with LF in combating bacteria. [5]

Antioxdants colostrum contains a lot of different types of anti-oxidants. Thus, women's dietary habits during pregnancy and lactation is importnat for the total antioxidant capacity of breast milk.

WHAT HAVE BEEN FOUND ABOUT COLOSTRUM RECENTLY?

The specific IgG from colostral antibodies of immunized bovine can provide effective protection or  therapy for multibacteria-induced diarrhea.

Researchers generated bovine colostral antibodies of cows immunized with a multivalent vaccine  consisting of whole cells of 17 strains of pathogenic diarrhea bacteria, and they purified the specific IgG with high activities against these pathogens.

The specific IgG was found to have a strong activity of inhibiting in vitro growth and colonization in pathogens by agglutinating with bacteria and destroying cell walls. Normal IgG purified from non-immunized bovine colostrum is incapable of eliciting the same consequences as specific IgG.
Specific IgG prevents enteroinvasive Escherichia coli/Salmonella typhi-induced diarrhea and may  exert an effective protection by enhancing splenic NK cell activity, elevating IL-2 level and inhibiting excessive release of TNF-alpha

Iimmunoglobulin (SIg) A prepared from colostrum pool greatly inhibit the invasion of enteroinvasive E. coli.  Researchers obtained  IgA preparations from colostrum and milk pools by salt precipitation.
They evaluated the final products in terms of yield and purity, as well as antibody activity to bacterial antigens and toxins and inhibitory activity of bacterial adhesion to epithelial cells. They used the colostrum pool with the best yield and purity as a source of IgA. They found that their IgA preparations preserved the antibody reactivity against various microbial antigens, well comparable with the reactivity exhibited by the original milk and colostrum pools. SIgA preparations were able to inhibit greatly the adhesion of enteropathogenic Escherichia coli to Hep-2 cells and the invasion of enteroinvasive E. coli.  [3]

Colostrum contains Neuropeptide – Ghrelin .
Ghrelin stimulates appetite by acting on the hypothalamic arcuate nucleus. The presence pf Ghrelin in blood stream under fasting conditions may transmit a hunger signal to the CNS or induces appetite stimulating effect.
.
Colostrum stimulates directly to i-IEL to polarize Th1 type, which may protect from infectious diseases and allergic diseases mediated by Th2 type responses. Researchers examined effects of oral administration of bovine colostrum on local immunity in intestine in adult mice. They supplied bovine colostrum or control milk orally to C57BL/6 mice for 1, 3 or 6 months. They then examined the intestinal microflora, fecal IgA, and lymphocyte population of gut-associated lymphoid tissues and their abilities of cytokine production.

Th1 stimulus for Th2-skewed immune response during infancy is important for reduction of incidence of allergic diseases.  The researchers found that the T cells in i-IEL were polarized to Th1 type after oral administration of bovine colostrum, though the cell populations of intestinal intraepithelial lymphocytes (i-IEL) were not remarkably changed.  And, oral administration of bovine colostrum does not change the Intestinal microflora and IgA levels in feces. [6]

Maternal vaccination with polyvalent pneumococcal polysaccharide vaccine boosts the capacity of colostrum to inhibit adherence of pneumococci to pharyngeal epithelial cells. In breast-feeding populations, maternal vaccination might prevent pneumococcal disease in young infants.
Researchers examined Colostrum obtained from Gambian mothers who had been vaccinated with either Pneumovax II or Mengivax A&C (n=8 per group) during pregnancy  for inhibition of adherence of Streptococcus pneumoniae serotypes 6B and 14 to pharyngeal epithelial cells in vitro. They found that pneumococcal adherence was significantly reduced in the presence of breast milk (P< or =.0001 for S. pneumoniae serotype 14; P=.036 for serotype 6B), independent of the concentration of secretory IgA antibodies. [8]

Bovine colostrum (BC) has been shown to improve athletic performance, reduce the incidence of upper respiratory tract infections, and reduce intestinal damage and permeability caused by the administration of non-steroidal antiinflammatory drugs. Research scientists found that
Supplementation with Bovine colostrum (BC) and whey protein during running training increases intestinal permeability in a study of 31 healthy subjects [9]

Human colostrum is a source of probiotics to infant during breastfeeding. Researchers analyzed 70 samples of milked human colostrum and they found  several classical groups of microorganisms: mesophylic (68.6%); thermoduric (38.6%); psychrotrophic (8.6%); proteolytic (15.7%); proteolytic-psychrotrophic (1,4%); lipolytic (4.3%); molds and yeasts (11.4%); Staphylococcus aureus (44.3%); total coliforms (7.2%); and lactic acid bacteria (37.2%), thus characterizing a diversified microbiota [13]

Colostrinin, a proline-rich polypeptide complex (PRP) isolated from bovine colostrum, with immunoregulatory and procognitive properties, has shown positive benefits in the treatment of Alzheimer's disease (AD). In a study, researchers treated 33 patients with Colostrinin tablets (containing 100 mg of PRP complex) every other day for three weeks, followed by a 2-week hiatus to avoid the development of hyporeactivity.  This mode of application, '3+2 weeks,' was used consistently throughout the 28 months trial. Researchers found Colostrinin induced slight but statistically significant improvement or stabilization of the health status of the patients in the trial. The side effects were emarkably mild, including anxiety, logorrhea, and insomnia, and subsided spontaneously within a short period of time (3-4 days). [12]

THE SIDE EFFECTS OF COLOSTRUM
Colostrum appears to be safe. But, long term use may induce mild side effects such as anxiety, logorrhea, and insomnia, and subsided spontaneously within a short period of time (3-4 days). [12]

REFERENCE [1]  Xu LB et al, Bovine immune colostrum against 17 strains of diarrhea bacteria and in vitro and in vivo effects of its specific IgG.Vaccine. 2005 Nov 15. [2] Thapa BR.Health factors in colostrum.Indian J Pediatr. 2005 Jul;72(7):579-81.[3] Carbonare CB et al, Secretory immunoglobulin A obtained from pooled human colostrum and milk for oral passive immunization. Pediatr Allergy Immunol. 2005 Nov;16(7):574-81[4]  Aydin S, Aydin S, Ozkan Y, Kumru S.. Ghrelin is present in human colostrum, transitional and mature milk.Peptides. 2005 Sep 24; .[5] Zimecki M, Artym J.Therapeutic properties of proteins and peptides from colostrum and milkPostepy Hig Med Dosw (Online). 2005 Jun 30;59:309-23.  [6] Yoshioka Y et al, Oral administration of bovine colostrum stimulates intestinal intraepithelial lymphocytes to polarize Th1-type in mice.Int Immunopharmacol. 2005 Mar;5(3):581-90. [7]  Ahmed L, et al, Antioxidant micronutrient profile (vitamin E, C, A, copper, zinc, iron) of colostrum: association with maternal characteristics.J Trop Pediatr. 2004 Dec;50(6):357-8. [8] Deubzer HE et al, Colostrum obtained from women vaccinated with pneumococcal vaccine during pregnancy inhibits epithelial adhesion of Streptococcus pneumoniae.J Infect Dis. 2004 Nov 15;190(10):1758-61. Epub 2004 Oct 7. [9]Buckley JD et al, Bovine colostrum and whey protein supplementation during running training increase intestinal permeability.Asia Pac J Clin Nutr. 2004;13(Suppl):S81. [10]  Alberti-Fidanza A et al, Total antioxidant capacity of colostrum, and transitional and mature human milk.J Matern Fetal Neonatal Med. 2002 Apr;11(4):275-9. [11] Fidler N et al, The fatty acid composition of human colostrum.Eur J Nutr. 2000 Feb;39(1):31-7.[12] Leszek J et  al, Colostrinin proline-rich polypeptide complex from ovine colostrum--a long-term study of its efficacy in Alzheimer's disease.Med Sci Monit. 2002 Oct;8(10):PI93-6.  [13]  
Novak FR et al, Human colostrum: a natural source of probiotics?J Pediatr (Rio J). 2001 Jul-Aug;77(4):265-70.

The very first nutrient source that was meant to supply the newborn’s deficient body with life sustaining energy, growth enhancing factors, immune building and stimulating substances and maternal messages of specific and unspecific nature is a complex liquid emulsion called Colostrum {pronounce kol-o:-strum}. Colostrum is a pre-milk liquid secretion that is produced within the mammary gland of a heavily gravid female, with virtually every single immune and immunity supporting cell of that female’s body involved. This life-giving liquid is designed to assist the neonate, shortly after the delivery, in the post-partum stage (within 0-6 hours), to overcome the perils of the transfer from a warm, sterile aquatic stage, to the cold, rough and unfriendly terrestrial world, filled with multitude of infective organisms, negative environmental influences and poisons. This truly miraculous liquid is without a doubt the most potent food source for a mammal (to which group the Homo Sapiens, means human belongs), and therefore the first “meal” of the colostrum is considered to be the most important one in human’s life. It has been proven in many re-known Institutes virtually worldwide, that infant morbidity and mortality are inversely affected by deficient breast-feeding of colostrum in the first 6 hours post-partum, and the early milk within 6-48 hours post partum. The importance of such feeding of colostrum can never be underestimated when it comes to the growth of the child and development of it’s own immune system.

IT’S NOT JUST FOR NEWBORN ANYMORE!!!

Just like in any innovative human activity, a “breakthrough” always signalizes the onset of a revolution. In the case of application of bovine colostrum in human nutrition, not just one “breakthrough”, but two have synergistically enhanced the motion towards this “live-giving” food. Not only for the neonates, but also for children, adolescent, and adults. As both of the breakthroughs happened principally in the same time, the author of this article does not want to give preferences in numerical order, therefore the marking will be as A and B./
Breakthrough “A”: The mammalian mother’s colostrum, is applicable to another mammalian species’ neonates, without adverse reactions, and with a certain degree of passive immune transfer, varying slightly from species to species, hence improving the neonates’ chances of survival. (J. Fredericksen Dr. et al., U of Idaho 1980; Prof. F. Hurnik, J. J. Smarda and M. Ostrowski; (1985) U of Guelph; Prof. J. Lavoie et al., U of Quebec, 1987) This breakthrough is so revolutionary, that it virtually shook the whole science of immunology in its foundations. The species’ specific theory of colostrum was so dramatically ingrained into the professional society, that even few decades before the 80s, the renegade heretics would be burned “at stake”. (the author is one of those who escaped unscathed)

Breakthrough “B”: This breakthrough is so revolutionary, that in spite of being known for nearly 2 decades, the scientific society has largely ignored it up to this era. In order to convince even the most “doubting Thomas’s”, the author will rather cite the flag-bearer of the revolution: …”it is of particular significance to realize that because the majority of benefits from the (bovine) colostral immune factors occur primarily within the lumen and on the intestinal and bronchial walls, most of colostrum' benefits are actually available to people of all ages. .….. this realization can be readily put to use by making colostrum supplementation available to individuals in need of improved health regardless of their age.” (Dr. D. Tyrrell, U of Harrow/London, 1980)  Parallelly with Dr. Tyrrell, a duo of Finish researchers confirmed (in 1980) [Dr. Sandholm and Dr. Honkanen-Buzalski] that “…bovine colostrum contains a powerful trypsin inhibitor with a high level of activity, which protects colostral immunoglobulins from digestive degradation.”  Dr. Von Fellenberg (1980) has confirmed these above mentioned facts as well, and added, that …”multiple protease inhibitors are present in colostrum, which serves as protection of its immune factors from stomach and intestinal degradation”.
At a later date, Prof. K. Bendick and Dr. H. Plettenberg of Germany have proven that the bovine colostral immunobodies are capable of “surviving” in gastric juices for nearly 24 hours (1992, Clinical Investigator), to offset the severe challenge of the doubting “scientific society”.

These 2 breakthroughs have provided a natural answer to the seekers of the ultimate health. The developer of products such as CLP/DCW, who has set his goals to slow down the biological clock, (which is ticking ever so faster, as we as humans impose upon ourselves more challenges in day-by-day fashion, from the outsidious world, as e. g. smog, mineral deficiencies in soils and therefore in our foods, excessive UV radiation, etc.), have reached as far as to the bovine source, which is plentiful, rich and potent. Quite obviously, collecting human colostrum would be the ideal answer. However, bovine colostrum is in its make up very close to the human one, and besides collecting human colostrum meets with a multitude of impracticalities.

As said, human colostrum immune “make-up” is very similar to such of bovine colostrum. The IgG, IgA and IgM profiles are very close. These 3 major immunoglobulins target majority of the harmful bacteria, viruses and yeast for neutralization, in a natural, non-clinical way.

IMMUNE STIMULATION

In colostrum, there are hundreds of various non-specific immune-stimulating factors, which are of great benefit to everyone’s health for the life’s duration. The Mother Nature has furnished the mammalian mothers with the “nutritional messenger” system (via colostrum and early milk flow), that in a superior way transfers the intended nutrients to the neonate and infant. However, the Mother Nature did not calculate with present “modern age” of severe depletions of soils and our foods, and ever increasing levels of poisonous substances in our environment, dangerous rays and electronic smog. Every healthy infant, born into a plentiful environment, is perfectly capable of producing its own specific and non-specific immune factors from the nutritional sources available. Nevertheless, today, in our highly diluted world, in order to enjoy high quality of our lives, we have to reach for concentrated means of nutrition, with bio-available immune factors, which shall compensate for the losses around us all.
To list all of the known non-specific immune factors in colostrum is not a task of this Product Introduction. This article would have to be many thousands of pages long. However, to document to the readers the benefits of such factors, the author will resort to just one chief set of substances, which are called Proline-Rich-Polypeptides (PRPs). The first scientist who conducted conclusive studies upon these long-chain immune-stimulating polypeptides, was Dr. K. Staroscik (1983) at the Polish Academy of Science in Wroclaw. She showed that the PRPs function as powerful regulators of immune system. In further research it was clearly shown that in humoral immune system’s response, the PRPs have stimulated low or, suppressed high (over-reactive) immune responses. PRPs have also shown beneficial effects on the maturation of thymocytes and the generation of the T-suppressor cells. This process will unquestionably bring equilibrium in body’s immune reactions.

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