Chemotherapy used for decades to fight cancer may actually stimulate the surrounding healthy cells, the secretion of a protein that supports growth and makes it "immune" to further cancer treatments. The discovery, "totally unexpected", was published in the journal Nature and is the result of a U.S. study on prostate cancer cells aimed to determine why these are so difficult to remove in the human body and are extremely easy to kill laboratory. Were analizzatigli effects of a type of chemotherapy on tissues collected from patients with prostate cancer.Have been discovered "evident in the DNA damage" in healthy cells around the area affected by cancer.
The latter produced higher quantities of the protein WNT16B which promotes the survival of tumor cells. The discovery that "the increase of WNT16B ... interacts with the neighboring tumor cells making them grow, propagate and, most importantly, get through the next anti-cancer ... it was totally unexpected," explained co-author Peter Nelson of the Fred Hutchinson Cancer Research Center in Seattle in Washington state. Confirms the novelty inter alia an element known from the times between the oncologists: tumors respond well to the first chemo except then grow rapidly and develop a greater resistance to further treatment chemioterapoci. Demonstrated by a given percentage of reproduction of the tumor cells among the various treatments. "Our results indicate that the damage in benign cells may directly contribute to increasing growth 'kinetics' of cancer," says the study, the researchers said, was also confirmed in breast and ovarian cancers. But the discovery could pave the way for the development of a treatment that does not produce this damaging side effect of chemotherapy: "For example, an antibody to the WNT16B, taken during the chemo, the married may migliorane killing more cancer cells. Another alternative would be to reduce the doses of chemo. "